2017


Banerjee G, Carare R, Cordonnier C, Greenberg SM, Schneider JA, Smith EE, et al. The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice. Journal of neurology, neurosurgery, and psychiatry. 2017.PDF. PMID: 28844070

Kraft P, Schuhmann MK, Garz C, Jandke S, Urlaub D, Mencl S, et al. Hypercholesterolemia induced cerebral small vessel disease. PLoS One. 2017;12(8):e0182822.PDF. PMID: 28796818

Diem A.K, MacGregor Sharp M, Gatherer M, Bressloff N.W, Carare R.O & Richardson G. Arterial pulsations cannot drive intramural periarterial drainage: Significance for Aβ drainage.Frontiers in Neuroscience. 2017;11(475).PDF

Wojtas AM, Kang SS, Olley BM, Gatherer M, Shinohara M, Lozano PA, et al. Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways. Proceedings of the National Academy of Sciences. 2017.PDF. PMID: 28701379

Diem, A.K. & Bressloff, N.W. VaMpy: A Python Package to Solve 1D Blood Flow Problems. Journal of Open Research Software. 2017;5(1), p.17.PDF

Held F, Morris AWJ, Pirici D, Niklass S, MacGregor Sharp M, Garz C, et al. Vascular basement membrane alterations and β-amyloid accumulations in an animal model of cerebral small vessel disease. Clinical Science. 2017. PDF

Engelhardt B, Vajkoczy P, Weller RO. The movers and shapers in immune privilege of the CNS. Nat Immunol. 2017;18(2):123-31. PDF PMID: 28092374

MacGregor Sharp M, Page A, Morris AWJ, Weller RO, Carare RO. Quantitative assessment of cerebral basement membranes using electron microscopy. in Inflammation: Methods and Protocols (eds. E. Clausen, B. & Laman, J.D.) 367-375 (Springer NY, 2017). PMID: 28063057

Albargothy JN, MacGregor Sharp M, Gatherer M, Morris AWJ, Weller RO, Hawkes CA, Carare RO. Investigating the Lymphatic Drainage of the Brain: Essential Skills and Tools. in Inflammation: Methods and Protocols (eds. E. Clausen, B. & Laman, J.D.) 343-365 (Springer NY, 2017). PMID: 28063056

2016


Engelhardt B, Carare RO, Bechmann B, Flügel A, Laman JD, Weller RO. Vascular, glial, and lymphatic immune gateways of the central nervous system. Acta Neuropathol. 2016;132(3):317-38 PDF. PMID: 27522506

Manousopoulou A, Gatherer M, Smith C, Nicoll JA, Woelk CH, Johnson M, Kalaria R, Attems J, Garbis SD, Carare RO. Systems proteomic analysis reveals that Clusterin and Tissue Inhibitor of Metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy. Neuropathol Appl Neurobiol. 2016. PDF. PMID: 27543695

Carare RO, Kalaria R. Cerebrovascular pathology: the dark side of neurodegeneration. Acta Neuropathologica. 2016:1-3. PDF. PMID:27062259

Bakker E.N, Bacskai B.J, Arbel-Ornath M, Aldea R, Bedussi B, Morris A.W.J, Weller R.O, Carare R.O . Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases. Cell Mol Neurobiol. 2016. PDF. PMID: 26993512

Morris AWJ, MacGregor Sharp M, Albargothy NJ, Hawkes CA, Verma A, Weller RO, Carare RO. Vascular basement membranes as pathways for the passage of fluid into and out of the brain. Acta Neuropathologica. 2016:1-12. PDF. PMID: 26975356

Nizari S, Carare RO, Hawkes CA. Increased Abeta pathology in aged Tg2576 mice born to mothers fed a high fat diet. Sci Rep. 2016;6:21981.PDF. PMID: 26911528

Weller RO, Hawkes CA, Carare RO. Lymphatic drainage of the brain and CSF: Relevance to neuroimmunology and Alzheimer’s disease. Neurology, Psychiatry and Brain Research. 2016;22(1):24.PDF.

Manousopoulou A, Saito S, Yamamoto Y, Al-Daghri NM, Ihara M, Carare RO, Garbis SD. Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model. Alzheimers Dis. 2016;51(2):333-8. PDF. PMID: 26836196

Coloma M, Schaffer JD, Carare RO, Chiarot PR, Huang P. Pulsations with reflected boundary waves: a hydrodynamic reverse transport mechanism for perivascular drainage in the brain. J Math Biol. 2016. PDF. PMID: 26729476

Weller RO, Carare RO, Hawkes CA, Galea I. Chapter 19 – Pathophysiology of Lymphatic Drainage of the Central Nervous System: Implications for the Pathophysiology of Multiple Sclerosis. In: Minagar A, editor. Multiple Sclerosis. San Diego: Academic Press; 2016. p. 479-501.

Diem AK, Tan M, Bressloff NW, Hawkes C, Morris AWJ, Weller RO, et al. A Simulation Model of Periarterial Clearance of Amyloid-beta from the Brain. Frontiers in Aging Neuroscience. 2016;8.PDF.

2015


Keable A, Fenna K, Yuen HM, Johnston DA, Smyth NR, Smith C, Salman R, Samarasekera N, Nicoll JAR, Attems J, Kalaria RN, Weller RO, Carare RO. Deposition of Amyloid β in the walls of human leptomeningeal arteries in relation to perivascular drainage pathways in cerebral amyloid angiopathy, Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Available online 29 August 2015. PDF. PMID:  26327684

Zekonyte J, Sakai K, Nicoll J, Weller RO, Carare RO. Quantification of molecular interactions between apoE,  Amyloid-beta (Aβ) and laminin: Relevance to accumulation of Aβ in Alzheimer’s disease, Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Available online 29 August 2015. PDF. PMID: 26327683

Osman S, Carare RO. Barriers faced by the people with dementia in the black and minority ethnic groups in accessing health care and social services. J Gerontol Geriatr Res 4:198. doi: 10.4172/2167-7182.1000198.

Tarasoff J, Carare RO, … Zlokovic B, Frangione B, Blennow K, Menard J, Zetterberg H, Wisniewski T de Leon M. Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol. 2015 Aug;11(8):457-70. PDF. PMID: 26195256

Weller RO, Hawkes CA, Carare RO, Hardy J. Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?. Acta Neuropathol, 2015 May;129(5):763-6. PDF. PMID: 25814152

Sharp, MK, Diem AK, Weller RO, Carare RO. Peristalsis with oscillating flow resistance: A mechanism for periarterial clearance of amyloid beta from the brain. Ann Biomed Eng. 2015 Sept 23. PMID: 26399987

Weller RO, Hawkes CA, Kalaria RN, Werring DJ, Carare RO. White matter changes in dementia: role of impaired drainage of interstitial fluid. Brain Pathology, 2015, Jan 25(1), 63-78. PMID: 25521178

Manousopoulou A, Woo J, Hawkes CA, Johnston H, Singhania A, Woelk CH, Garbis SD, Carare RO. You also are what your mother eats: Distinct proteomic portrait as a result of maternal high-fat diet in the cerebral cortex of the adult mouse. Int J Obes (Lond). 2015 Aug;39(8):1325-8. PMID: 25797609

Rusted J & Carare RO. Are the effects of APOE ϵ4 on cognitive function in nonclinical populations age- and gender-dependent?. Neurodegenerative Dis Manag, 2015 Feb;5(1):37-48. PMID: 25711453

2014


Hawkes CA, Gentleman S, Nicoll JAR, Carare RO. Prenatal high fat diet alters the cerebrovasculature and clearance of beta-amyloid in adult offspring. J Pathol. 2014 Oct 24. doi: 10.1002/path.4468. PMID: 25345857

Morris A.W, Carare RO, Schreiber S, Hawkes CA. The cerebrovascular basement membrane: role in the clearance of β-amyloid and Cerebral Amyloid Angiopathy. Front Aging Neuroscience, 2014 Sep 19;6:251. PMID: 25285078

Hawkes CA, Jayakody N, Johnston DA, Bechmann I, Carare RO. Failure of perivascular drainage of beta-amyloid in cerebral amyloid angiopathy. Brain Pathol. 2014 Jul;24(4):396-403. PMID: 24946077

Bueche CZ, Garz C,….Carare RO, Schreiber S. Impact of N-acetylcysteine on cerebral parenchymal Aβ plaques and kidney damage in spontaneously hypertensive stroke-prone rats. Journal of Alzheimer’s disease, 2014 42 Suppl 3:S305-13. PMID: 24898644

Sakai, Kenji, Boche, Delphine, Carare, Roxana, Johnston, David, Holmes, Clive, Love, Seth and Nicoll, James A R. (2014) Aß immunotherapy for Alzheimer’s disease: effects on apoE and cerebral vasculopathy. Acta Neuropathologica, 128, (6), 777-789. (doi:10.1007/s00401-014-1340-9). PMID:25195061

Hawkes, Cheryl A., Carare, Roxana O. and Weller, Roy O. (2014) Amyloid and tau in the brain in sporadic Alzheimer’s disease: defining the chicken and the egg. Acta Neuropathologica, 127, (4), 617-618. (doi:10.1007/s00401-014-1243-9). PMID: 24452628

Bueche, Celine Z., Hawkes, Cheryl, Garz, Cornelia, Vielhaber, Stefan, Attems, Johannes, Knight, Robert T., Reymann, Klaus, Heinze, Hans-Jochen, Carare, Roxana O. and Schreiber, Stefanie. (2014) Hypertension drives parenchymal ß-amyloid accumulation in the brain parenchyma. Annals of Clinical and Translational Neurology (doi:10.1002/acn3.27). PMID: 25356391

2013


Hawkes, Cheryl A., Shaw, James E., Brown, Mary, Sampson, Anthony P., McLaurin, JoAnne and Carare, Roxana O. (2013) MK886 reduces cerebral amyloid angiopathy severity in TgCRND8 mice. Neurodegenerative Diseases, 1-7. (doi:10.1159/000351096). PMID: 24021653

Carare, Roxana, Teeling, Jessica, Hawkes, Cheryl A, Püntener, Ursula, Weller, Roy O, Nicoll, James AR and Perry, Victor. (2013) Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer’s disease. Acta Neuropathologica, 1, (1), 48-[11pp]. (doi:10.1186/2051-5960-1-48). PMID: 24252464

Hawkes, C.A., Gatherer, M., Sharp, M.M., Dorr, A., Yuen, H.M., Kalaria, R., Weller, R.O. and Carare, R.O. (2013) Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain. Aging Cell, 12, (2), 224-236. (doi:10.1111/acel.12045). PMID  23413811 

Hawkes, C.A., Zekonyte, J., Howard, K., Nicoll, James A.R., Weller, Roy O. and Carare, Roxana O. (2013) Apolipoprotein E epsilon 4 (apoE4) may impair perivascular elimination of amyloid-beta (A beta). Neuropathology and Applied Neurobiology, 39, supplement 1, 8. (doi:10.1111/j.1365-2990.2013.12029.x).

2012


Hawkes, C.A., Sullivan, P.M., Hands, S., Weller, R.O., Nicoll, J.A.R. and Carare, Roxana O. (2012) Disruption of arterial perivascular drainage of amyloid-ß from the brains of mice expressing the human APOE e4 allele. PLoS ONE, 9, (8), 890-901. (doi:10.1371/journal.pone.0041636). PMID: 22848551

Teeling, Jessica L., Carare, Roxana O., Glennie, Martin J. and Perry, V. Hugh. (2012) Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction. Acta Neuropathologica, 124, (4), 479-490. (doi:10.1007/s00401-012-0995-3). PMID: 22618994

2011


Hawkes, Cheryl A., Härtig, Wolfgang, Kacza, Johannes, Schliebs, Reinhard, Weller, Roy O., Nicoll, James A.R. and Carare, Roxana O. (2011) Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy. Acta Neuropathologica, 121, (4), 431-443. (doi:10.1007/s00401-011-0801-7). (PMID:21259015). PMID:  21259015

Coleman, Peter G., Carare, Roxana O., Petrov, Ignat, Forbes, Elizabeth, Saigal, Anita, Spreadbury, John H., Yap, Andrea and Kendrick, Tony. (2011) Spiritual belief, social support, physical functioning and depression among older people in Bulgaria and Romania. Aging & Mental Health, 15, (3), 327-333. (doi:10.1080/13607863.2010.519320). PMID: 21491217

2010


Weller, Roy O., Galea, Ian, Carare, Roxanna O. and Minagar, Alireza. (2010) Pathophysiology of the lymphatic drainage of the central nervous system: implications for pathogenesis and therapy of multiple sclerosis. Pathophysiology, 17, (4), 295-306. (doi:10.1016/j.pathophys.2009.10.007). PMID: 19954936

Keage, Hannah A., Carare, Roxanna O., Friedland, Robert P., Ince, Paul G., Love, Seth, Nicoll, James A., Wharton, Stephen B., Weller, Roy O. and Brayne, Carol. (2010) Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review. BMC Neurology, 9, (3) (doi:10.1186/1471-2377-9-3). PMID: 19144113

2009


Clapham, R., O’Sullivan, E., Weller, Roy and Carare, Roxana Octavia. (2009) Cervical lymph nodes are found in direct relationship with the internal carotid artery: Significance for the lymphatic drainage of the brain. Clinical Anatomy, 23, (1), 43-47. (doi:10.1002/ca.20887). PMID: 19918869

Carare, Roxana-Octavia, Preston , S.D., Subash, M. and Weller, R.O. (2009) Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease. Alzheimer’s Research & Therapy, 1, (2) (doi:10.1186/alzrt6). PMID: 19822028

Weller, Roy O., Djuanda, Effie., Yow, Hong-Yeen and Carare, Roxana O. (2009) Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathologica, 117, (1), 1-14. (doi:10.1007/s00401-008-0457-0). PMID: 19002474

Weller, R.O., Boche, D. & Nicoll, J.A. Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy. Acta Neuropathol 118, 87-102 (2009).

Keage, H.A., et al. Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review. BMC Neurol 9, 3 (2009).

 

2008


Carare, R.O. and Goodwin, M. (2008) Compendium of anatomical variants: a unique variation of the sciatic nerve. Clinical Anatomy, 21, (8), 800-801. (doi:10.1002/ca.20696). PMID: 18773477

de Silva, Prasanna, Carare, Roxana O. and Weller, Roy O. (2008) Failure of elimination of amyloid-beta from the brain in Alzheimer’s disease. Progress in Neurology and Psychiatry, 12, (4), 6-10. (doi:10.1002/pnp.72).

Carare, R.O., Bernardes-Silva, M., Newman, T.A., Page, A.M., Nicoll, J.A.R., Perry, V.H. and Weller, R.O. (2008) Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathology & Applied Neurobiology, 34, (2), 131-144. (doi:10.1111/j.1365-2990.2007.00926.x). PMID: 18208483

Weller, Roy O., Subash, Malavika, Preston, Stephen D., Mazanti, Ingrid and Carare, Roxana O. (2008) Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer’s disease. Brain Pathology, 18, (2), 253-266. (doi:10.1111/j.1750-3639.2008.00133.x). PMID: 18363936

2007


● Campbell, S.J., Carare-Nnadi, R.O., Losey, P.H. and Anthony, D.C. (2007) Loss of atypical inflammatory response in juvenile and aged rats. Neuropathology and Applied Neurobiology, 33, (1), 108-120. (doi:10.1111/j.1365-2990.2006.00773.x). PMID 17239013

2006


Schley, D., Carare-Nnadi, R., Please, C.P., Perry, V.H. and Weller, R.O. (2006) Mechanisms to explain the reverse perivascular transport of solutes out of the brain. Journal of Theoretical Biology, 238, (4), 962-974. (doi:10.1016/j.jtbi.2005.07.005). PMID: 16112683

2005


O’Sullivan, E., Carare-Nnadi, R., Greenslade, J. and Bowyer, G. (2005) Clinical significance of variations in the nterconnections between flexor digitorum longus and flexor hallucis longus in the region of the knot of Henry. Clinical Anatomy, 18, (2), 121-125. (doi:10.1002/ca.20029). PMID: 15696523

Li, R., et al. Glial fibrillary acidic protein mutations in infantile, juvenile, and adult forms of Alexander disease. Ann Neurol 57, 310-326 (2005).

Salzman, K.L., et al. Giant tumefactive perivascular spaces. AJNR Am J Neuroradiol 26, 298-305 (2005).

Weller, R.O. & Nicoll, J.A. Cerebral amyloid angiopathy: both viper and maggot in the brain. Ann Neurol 58, 348-350
(2005).

Weller, R.O. Microscopic morphology and histology of the human meninges. Morphologie 89, 22-34 (2005).

2004


Weller, R.O., Cohen, N.R. & Nicoll, J.A. Cerebrovascular disease and the pathophysiology of Alzheimer’s disease.
Implications for therapy.
Panminerva Med 46, 239-251 (2004).

Horstmann, S., et al. Genetic and expression profiles of cerebellar liponeurocytomas. Brain Pathol 14, 281-289 (2004).

Sun, D., Newman, T.A., Perry, V.H. & Weller, R.O. Cytokine-induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis. Neuropathol Appl Neurobiol 30, 374-384 (2004).

Nicoll, J.A., Yamada, M., Frackowiak, J., Mazur-Kolecka, B. & Weller, R.O. Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer’s disease. Pro-CAA position statement. Neurobiol Aging 25, 589-597; discussion 603-584 (2004).

Preece, N.E., Houseman, J., King, M.D., Weller, R.O. & Williams, S.R. Development of vigabatrin-induced lesions in the rat brain studied by magnetic resonance imaging, histology, and immunocytochemistry. Synapse 53, 36-43 (2004).

Fowler, M.I., Weller, R.O., Heckels, J.E. & Christodoulides, M. Different meningitis-causing bacteria induce distinct inflammatory responses on interaction with cells of the human meninges. Cell Microbiol 6, 555-567 (2004).

2003


Weller, R.O. & Nicoll, J.A. Cerebral amyloid angiopathy: pathogenesis and effects on the ageing and Alzheimer brain. Neurological research 25, 611-616 (2003).

Nicoll, J.A. & Weller, R.O. A new role for astrocytes: beta-amyloid homeostasis and degradation. Trends Mol Med 9, 281-282 (2003).

Hien, T.T., et al. Neuropathological assessment of artemether-treated severe malaria. Lancet 362, 295-296 (2003).

Roher, A.E., et al. Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer’s disease. Mol Med 9, 112-122 (2003).

Zhang, B., et al. Molecular pathogenesis of subarachnoid haemorrhage. Int J Biochem Cell Biol 35, 1341-1360 (2003).

Preston, S.D., Steart, P.V., Wilkinson, A., Nicoll, J.A. & Weller, R.O. Capillary and arterial cerebral amyloid angiopathy in Alzheimer’s disease: defining the perivascular route for the elimination of amyloid beta from the human brain. Neuropathol Appl Neurobiol 29, 106-117 (2003). 

Nicoll, J.A., et al. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9, 448-452 (2003).

2002


Weller, R.O., Yow, H.Y., Preston, S.D., Mazanti, I. & Nicoll, J.A. Cerebrovascular disease is a major factor in the failure of elimination of Abeta from the aging human brain: implications for therapy of Alzheimer’s disease. Ann N Y Acad Sci 977, 162-168 (2002).

Christodoulides, M., et al. Interaction of Neisseria meningitidis with human meningeal cells induces the secretion of a distinct group of chemotactic, proinflammatory, and growth-factor cytokines. Infect Immun 70, 4035-4044 (2002).

2001


Kuo, Y.M., et al. The evolution of A beta peptide burden in the APP23 transgenic mice: implications for A beta deposition in Alzheimer disease. Mol Med 7, 609-618 (2001).

Hilton, D.A. & Weller, R.O. Autopsy investigation of disorders of skeletal muscle and peripheral nerves. Curr Top Pathol 95, 207-238 (2001).

Weller, R.O. & Preston, S.D. The spectrum of vascular disease in dementia. From ischaemia to amyloid angiopathy. Adv Exp Med Biol 487, 111-122 (2001).

Weller, R.O. How well does the CSF inform upon pathology in the brain in Creutzfeldt-Jakob and Alzheimer’s diseases? J Pathol 194, 1-3 (2001).

Weller, R.O. XlVth International Congress of Neuropathology, 3-6 September, 2000, Birmingham, United Kingdom. Brain Pathol 11, 250-258 (2001).

2000


Sun, D., et al. Role of chemokines, neuronal projections, and the blood-brain barrier in the enhancement of cerebral EAE following focal brain damage. J Neuropathol Exp Neurol 59, 1031-1043 (2000).

Kuo, Y.M., et al. Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer’s disease. Mol Med 6, 430-439 (2000).

Hardy, S.J., Christodoulides, M., Weller, R.O. & Heckels, J.E. Interactions of Neisseria meningitidis with cells of the human meninges. Mol Microbiol 36, 817-829 (2000).

Weller, R.O., Massey, A., Kuo, Y.M. & Roher, A.E. Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer’s disease. Ann N Y Acad Sci 903, 110-117 (2000).