Anhydrase Inhibitors to treat Alzheimer’s Disease

The Edward N. and Della L. Thome Memorial Foundation collaborative project with Dr. Silvia Fossati, Unniversity of Pennsylvania

Here, we will test the overarching hypothesis that Carbonic Anhydrase Inhibitors have the potential to prevent mitochondrial and cell death pathways induced by the deposition of Aβ in its intramural periarterial drainage pathways around the cerebral SMCs, preventing/delaying CAA.