What is IPAD?

Apart from the blood, there are two fluids associated with the brain: cerebrospinal fluid (CSF) and interstitial fluid (ISF). CSF drains through arachnoid villi into the blood and via routes adjacent to olfactory nerves into the nasal mucosa, cervical and dural lymphatics….
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Strategies for improving IPAD?

Phosphodiesterase III is the major cAMP-hydrolyzing PDE uniquely expressed in vascular smooth muscle cells; PDE IIIA isoforms are also involved in cardiovascular function by regulating vascular smooth muscle growth and phenotypic changes…..
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Strategies for improving IPAD?

Phosphodiesterase III is the major cAMP-hydrolyzing PDE uniquely expressed in vascular smooth muscle cells; PDE IIIA isoforms are also involved in cardiovascular function by regulating vascular smooth muscle growth and phenotypic changes…..
Read more

Current projects

Anhydrase Inhibitors to treat Alzheimer’s Disease

Anhydrase Inhibitors to treat Alzheimer’s Disease

Anhydrase Inhibitors to treat Alzheimer's DiseaseThe Edward N. and Della L. Thome Memorial Foundation collaborative project with Dr. Silvia Fossati, Unniversity of PennsylvaniaHere, we will test the overarching hypothesis that Carbonic Anhydrase Inhibitors have the...

Noradrenergic regulation of amyloid clearance in AD

Noradrenergic regulation of amyloid clearance in AD

Noradrenergic regulation of amyloid clearance in ADBrightFocus Foundation (USA) collaboration with Michigan State UniversityIn this project we will test the extent to which noradrenergic locus coeruleus (LC) and cholinergic basal forebrain (CBF) projection system...

The link between locus coeruleus degeneration and IPAD

The link between locus coeruleus degeneration and IPAD

Locus coeruleus and the basal forebrain degenerate early in AD and it is possible that the deficient adrenergic or cholinergic supply lead to a failure of IPAD.ARUK Network Cooperation funding between Newcastle University and the University of SouthamptonThe exact...

Innervation of cerebral arteries is key to maintenance of IPAD

Innervation of cerebral arteries is key to maintenance of IPAD

Innervation of cerebral arteries is key to maintenance of efficient clearance and flowAlzheimer’s Research UK – Co-PI “Targeting perivascular innervation and vascular tone for improved clearance of ß-amyloid from the brain“. £88,440This project, funded by Alzheimer’s...

Failure of IPAD in vascular dementia

Failure of IPAD in vascular dementia

Failure of drainage of fluid from the brain along the walls of blood vessels in vascular dementiaStroke Association Priority Programme Award (vascular dementia) –  £245,198.00Cerebral small vessel disease (SVD) is a key feature of vascular dementia, radiologically...

Immunisation Strategies for Synucleinopathies

Immunisation Strategies for Synucleinopathies

Investigating Immunisation Strategies for the Treatment of SynucleinopathiesMedical Research Council UK & United Neuroscience project grant –  £70,000Next generation immunisation strategies have enabled the manufacture of highly efficacious vaccines to treat major...

Clusterin is a key molecule that improves IPAD

Clusterin is a key molecule that improves IPAD

Clusterin is a key molecule that improves IPADJapan Society of Science fellowship – £140,000Genome-wide association studies of sporadic Alzheimer’s disease have demonstrated variations in the gene encoding clusterin, a disulfide linked heterodimeric glycoprotein....

TUBE: Transport Derived Ultrafines and their Brain Effects

TUBE: Transport Derived Ultrafines and their Brain Effects

TUBE: Transport Derived Ultrafines and their Brain EffectsHorizon 2020 TUBE-LC-MG-2018 – “Transport derived ultrafines and their brain effects“. £239,039Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include...

The link between Amyloid-beta and alpha-Synuclein pathology

The link between Amyloid-beta and alpha-Synuclein pathology

Investigating the link between Amyloid-beta and alpha-Synuclein pathologyCollaborative project with REDSHIFTbioLewy Body (LB) diseases are one of the most common neurodegenerative disorders, second to Alzheimer’s disease (AD), and comprise of Parkinson’s disease (PD),...