Innervation of cerebral arteries is key to maintenance of efficient clearance and flow

Alzheimer’s Research UK – Co-PI “Targeting perivascular innervation and vascular tone for improved clearance of ß-amyloid from the brain“. £88,440

This project, funded by Alzheimer’s Research UK in collaboration with Dr Cheryl Hawkes (Open University), tests the hypothesis that loss of perivascular innervation by cholinergic neurons leads to dysfunctional regulation of vascular tone, thereby reducing the motive force for perivascular drainage of Aβ leading to a worsening of cerebral amyloid angiopathy.