Locus coeruleus and the basal forebrain degenerate early in AD and it is possible that the deficient adrenergic or cholinergic supply lead to a failure of IPAD.

ARUK Network Cooperation funding between Newcastle University and the University of Southampton

The exact location and changes with age and AD for the receptors for adrenergic and cholinergic supply specific for the arteries are not known, In this network collaboration project, by combining the expertise of human CAA (Prof Johannes Attems, Newcastle University) and neurovascular anatomy (Carare, University of Southampton), we aim to define the distribution of the adrenergic and cholinergic receptors in the walls of blood vessels, in relation to pyroglutamate Aβ. Our results will contribute to a novel therapeutic strategy for AD, based on facilitating IPAD and preventing CAA.