Professor Roxana Carare and Professor Roy O Weller established the Carare Group in 2008 at the University of Southampton. The aim was to elucidate the significance of cerebral Amyloid Beta clearance to age related pathological conditions such as Cerebral Amyloid Angiopathy and Alzheimer’s Disease. We are internationally recognised for defining the exact pathway from which Amyloid Beta and other solutes are cleared from the brain along cerebral basement membranes. We now aim to clarify the exact factors that are responsible for efficient drainage along basement membranes of capillaries and arteries in order to identify new therapeutic targets.

We are a diverse group employing scientists from specialities such as Electron Microscopy, Proteomics, Tissue culture, and immunohistochemistry as well as facilitating advancement in education in the form of Masters and PHD studentships. We regularly coordinate and manage research projects for undergraduate students and collaborate internationally with other research institutions and several industry partners.