the carare research group
Professor Roxana Carare and the late Professor Roy O Weller established the Carare Group in 2008 at the University of Southampton. The aim was to elucidate the significance of cerebral Amyloid Beta clearance to age related pathological conditions such as Cerebral Amyloid Angiopathy and Alzheimer’s Disease.
The group are internationally recognised for defining the exact pathway from which Amyloid Beta and other solutes are cleared from the brain along cerebral basement membranes. The main objective now is to clarify the exact factors that are responsible for efficient drainage along basement membranes of capillaries and arteries in order to identify new therapeutic targets.
fluid clerance in the brain
Apart from the blood, there are two fluids associated with the brain: cerebrospinal fluid (CSF) and interstitial fluid (ISF). CSF drains through arachnoid villi into the blood and via routes adjacent to olfactory nerves into the nasal mucosa, cervical and dural lymphatics. This route permits the drainage of antigen presenting cells from the subarachnoid space into the lymphatic system….
STRATEGIES FOR IMPROVING IPAD
Phosphodiesterase III is the major cAMP-hydrolyzing PDE uniquely expressed in vascular smooth muscle cells; PDE IIIA isoforms are also involved in cardiovascular function by regulating vascular smooth muscle growth and phenotypic changes. Cilostazol is a selective inhibitor of PDE III that increases cAMP in vascular cells and has multiple effects on the vasculature such as vasodilatation….
Targeted CSF drug delivery
The recent major success in the treatment of neurodegenerative diseases has been provided by intrathecal administration of anti-sense oligonucleotides (ASOs) in the form of Nusirensen, invented by Biogen and IONIS. Our group has demonstrated the exact pathways that small molecules take from the cerebrospinal compartment into the brain parenchyma and this pathway is….