Professor Roxana Carare and Professor Roy O Weller established the Carare Group in 2008 at the University of Southampton. The aim was to elucidate the significance of cerebral Amyloid Beta clearance to age related pathological conditions such as Cerebral Amyloid Angiopathy and Alzheimer’s Disease.

The group are internationally recognised for defining the exact pathway from which Amyloid Beta and other solutes are cleared from the brain along cerebral basement membranes. The main objective now is to clarify the exact factors that are responsible for efficient drainage along basement membranes of capillaries and arteries in order to identify new therapeutic targets.