Noradrenergic regulation of amyloid clearance in AD

BrightFocus Foundation (USA) collaboration with Michigan State University

In this project we will test the extent to which noradrenergic locus coeruleus (LC) and cholinergic basal forebrain (CBF) projection system degeneration contributes to the progression of AD by disrupting the clearance of amyloid-β (Aβ) peptides from the brain via the IPAD pathway.